In Autism from the gut? I hypothesized that a source for autism should be looked at in the gut.
Jurgensen sent me a reference to Gut Bacteria Linked to Behavior: That Anxiety May Be in Your Gut, Not in Your Head (ScienceDaily, May 17, 2011) that in turns points out to The Intestinal Microbiota Determines Mouse Behavior and Brain BDNF Levels, by Emmanuel Denou, Wendy Jackson, Jun Lu, Patricia Blennerhassett, Kathy McCoy, Elena F. Verdu, Stephen M. Collins, and Premysl Bercik (Gastroenterology, Vol. 140, Issue 5, Supplement 1, Page S-57).
ScienceDaily mentions a possible relation to autism, but the article itself doesn't. What the article points to in terms of the influence of gut bacteria is:
Exploratory behaviour was reduced in GF NIH Swiss mice colonized with BALB/c microbiota, and increased in GF BALB/c mice colonized with NIH Swiss microbiota compared to mice colonized with their respective SPF microbiota
and
At 1 week post-transfer, mice colonized with BALB/c microbiota showed 44% reduction in hippocampal BDNF compared to mice with NIH Swiss microbiota, however at 3 weeks post-transfer, their hippocampal BDNF levels were similar
Regarding the first finding, my observation is that autistic subjects are both less exploratory (routines) and more (specific subjects). That would indeed fit .
Regarding the second finding, which has to do with learning and recall, I don't know. Cf. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition, by Vaynman S, Ying Z, Gomez-Pinilla F. (Eur J Neurosci. 2004 Nov;20(10):2580-90).
Bertrand du Castel
Jurgensen sent me a reference to Gut Bacteria Linked to Behavior: That Anxiety May Be in Your Gut, Not in Your Head (ScienceDaily, May 17, 2011) that in turns points out to The Intestinal Microbiota Determines Mouse Behavior and Brain BDNF Levels, by Emmanuel Denou, Wendy Jackson, Jun Lu, Patricia Blennerhassett, Kathy McCoy, Elena F. Verdu, Stephen M. Collins, and Premysl Bercik (Gastroenterology, Vol. 140, Issue 5, Supplement 1, Page S-57).
ScienceDaily mentions a possible relation to autism, but the article itself doesn't. What the article points to in terms of the influence of gut bacteria is:
Exploratory behaviour was reduced in GF NIH Swiss mice colonized with BALB/c microbiota, and increased in GF BALB/c mice colonized with NIH Swiss microbiota compared to mice colonized with their respective SPF microbiota
and
At 1 week post-transfer, mice colonized with BALB/c microbiota showed 44% reduction in hippocampal BDNF compared to mice with NIH Swiss microbiota, however at 3 weeks post-transfer, their hippocampal BDNF levels were similar
Regarding the first finding, my observation is that autistic subjects are both less exploratory (routines) and more (specific subjects). That would indeed fit .
Regarding the second finding, which has to do with learning and recall, I don't know. Cf. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition, by Vaynman S, Ying Z, Gomez-Pinilla F. (Eur J Neurosci. 2004 Nov;20(10):2580-90).
Bertrand du Castel
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